Posts by Brokeback Watchtower

88

Legalized marijuana. It's coming to canada and I want to try it.

by hoser in

jw
friends

as a good jw i never smoked a joint or nibbled on some brownies.

Brokeback Watchtower

When a person is in psychic pain, they feel it intensely and are forced to deal with it. That makes a lot of sense.

THC has the ability to make conscious some of the things we have suppressed in the unconscious and yes dealing with it is much better(to which I might add micro dosing with iboga root bark(1/2 gram every 4 days) has the added benefit a disassociative so you can relive trauma without the intense emotional pains and process it with the prefrontal lobes I think it is excellent for PTSD, and XJdubs that are dealing with deprogramming themselves from the indoctrinated mind set as this will help you go deeper to root out all that bull shit you had to listen to 3 times a week.

http://www.ibogaworld.com/

88

Legalized marijuana. It's coming to canada and I want to try it.

by hoser in

jw
friends

as a good jw i never smoked a joint or nibbled on some brownies.

Brokeback Watchtower

No promotes it in cancer cells CBD mainly :

http://mct.aacrjournals.org/content/10/7/1161.full

annabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
Ashutosh Shrivastava,
Paula M. Kuzontkoski,
Jerome E. Groopman, and
Anil Prasad
+Author Affiliations
Authors' Affiliation: Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
Corresponding Author:
Anil Prasad, Division of Experimental Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215. Phone: 617-667-0703; Fax: 617-975-5244; E-mail: [email protected]
Next SectionAbstract
Cannabidiol (CBD), a major nonpsychoactive constituent of cannabis, is considered an antineoplastic agent on the basis of its in vitro and in vivo activity against tumor cells. However, the exact molecular mechanism through which CBD mediates this activity is yet to be elucidated. Here, we have shown CBD-induced cell death of breast cancer cells, independent of cannabinoid and vallinoid receptor activation. Electron microscopy revealed morphologies consistent with the coexistence of autophagy and apoptosis. Western blot analysis confirmed these findings. We showed that CBD induces endoplasmic reticulum stress and, subsequently, inhibits AKT and mTOR signaling as shown by decreased levels of phosphorylated mTOR and 4EBP1, and cyclin D1. Analyzing further the cross-talk between the autophagic and apoptotic signaling pathways, we found that beclin1 plays a central role in the induction of CBD-mediated apoptosis in MDA-MB-231 breast cancer cells. Although CBD enhances the interaction between beclin1 and Vps34, it inhibits the association between beclin1 and Bcl-2. In addition, we showed that CBD reduces mitochondrial membrane potential, triggers the translocation of BID to the mitochondria, the release of cytochrome c to the cytosol, and, ultimately, the activation of the intrinsic apoptotic pathway in breast cancer cells. CBD increased the generation of reactive oxygen species (ROS), and ROS inhibition blocked the induction of apoptosis and autophagy. Our study revealed an intricate interplay between apoptosis and autophagy in CBD-treated breast cancer cells and highlighted the value of continued investigation into the potential use of CBD as an antineoplastic agent. Mol Cancer Ther; 10(7); 1161–72. ©2011 AACR.Previous Section Next SectionIntroduction
Breast cancer is the second leading cause of cancer-related death in women in the United States (1). Conventional treatment options are often limited by toxicity or acquired resistance, and novel agents are needed. We analyzed the effects of the Cannabis sativaconstituent, cannabidiol (CBD), a potent, natural compound with reported activity in breast cancer cell lines, and elucidated its effects on key neoplastic pathways.
CBD belongs to the cannabinoid family, a group of pharmacologically active compounds that bind to specific G-protein–coupled receptors (2). Phytocannabinoids are plant-derived products from Cannabis sativa; endogenous cannabinoids are made in animal and human tissues; and synthetic cannabinoids are laboratory produced. The G-protein–coupled receptor CB1 is found mainly in the brain and nervous system, whereas CB2 is expressed predominantly by immune cells (3). Recent data suggest that some cannabinoids also signal through the vallinoid receptor (4), whereas others may function in a receptor-independent manner (3). Cannabinoids can modulate signaling pathways central to the growth and spread of cancer. They inhibit cell-cycle progression and chemotaxis, and block angiogenesis (5). Recent studies have shown that cannabinoids also induce autophagic cell death (6). Δ9-tetrahydrocannabinol (THC) is one of the best-characterized cannabinoids; however, its therapeutic applications are limited by its psychoactive effects. We focused our work on CBD, a phytocannabinoid devoid of these properties (3).
Although CBD is reportedly effective against various tumors, its molecular mechanism of action is not fully characterized. CBD is cytotoxic to gliomas and inhibits tumor cell migration in vitro (7–9). In addition, CBD induces apoptosis in human leukemia cell lines by activating classical caspase pathways, and enhancing NOX4 and p22 (PHOX) function (10). A recent study reports that CBD inhibits breast cancer growth (11) and downregulates ID1, a regulator of metastasis in breast cancer cell lines (12). Furthermore, CBD, in conjunction with THC, induces programmed cell death (PCD) in glioma cells (13).
PCD, a cell suicide program critical to development and tissue homeostasi........

31

Obama to speak from the Oval Office tonight (8:00 eastern)

by Coded Logic in

this will be only the 3rd time he's spoken from the oval office in his seven years so it's probably going to be something pretty big.

combat troops being sent into syria?

unilateral movement on gun control?.

Brokeback Watchtower

http://www.cnn.com/2015/12/05/politics/obama-to-discuss-terror-threats/index.html

88

Legalized marijuana. It's coming to canada and I want to try it.

by hoser in

jw
friends

as a good jw i never smoked a joint or nibbled on some brownies.

Brokeback Watchtower

Yeah! should bring down the price and make it easily availible to all who want it. It's a neural protector, reduces brain inflamation, promotes apoptosis. Get some with a high CBD ratio as it potentiates the beneficial effect of THC and reduces some of the psychoactive effect bringing about a kind of clearity. Stroke patients should take plenty of this orally these two cannibinoids as it reduces further damage.

155

Survey: How long were you in the cult vs what year you were baptized

by ILoveTTATT2 in

jw
friends

hi people,.

i want as much data as possible on the effect of the internet on the time captured by the cult.. please answer the three following questions about yourself or about someone you know (for example, if your parents or grandparents were jw's and left).

1) were you raised as a jw, or did you convert?.

Brokeback Watchtower

1 No

2 1972

3 2001

67

Scriptures that will never be the YEAR TEXT

by ttdtt in

so what scriptures do you think will never make the cut?i will start off with one to warm you all up.. 1 corinthians 4:6 - do not go beyond the things that are written,.

Brokeback Watchtower

Psalm 137:9:

Happy will be the one who seizes your children And dashes them against the rocks.

27

I've begun reading the Qur'an

by nicolaou in

i've reached the point where i feel legitimate comment needs to be backed by knowledge of the source.. i'll post occasional updates on how i'm doing and what i'm learning .

.

..

Brokeback Watchtower

Well more power to you if read the whole thing the most that I want to do is get a little history so I would just do a wiki search on Muhammad for an abbreviated history:

https://en.wikipedia.org/wiki/Muhammad

Beginnings of the Quran
See also: Muhammad's first revelation, History of the Quran and Wahy
The cave Hira in the mountain Jabal al-Nourwhere, according to Muslim belief, Muhammad received his first revelation.
Muhammad began to pray alone in a cave named Hira on Mount Jabal al-Nour, near Mecca for several weeks every year.[59][60] Islamic tradition holds that during one of his visits to that cave, in the year 610 the angel Gabriel appeared to him and commanded Muhammad to recite verses that would be included in the Quran.[61] Consensus exists that the first Quranic words revealed were the beginning of Surah 96:1.[62] Muhammad was deeply distressed upon receiving his first revelations. After returning home, Muhammad was consoled and reassured by Khadijah and her Christian cousin, Waraqah ibn Nawfal.[63] Waraqah is variously described as an Ebionite priest (possibly of Mecca) or Nestorian. He also feared that others would dismiss his claims as being possessed.[39] Shi'a tradition states Muhammad was not surprised or frightened at Gabriel's appearance; rather he welcomed the angel, as if he was expected.[64] The initial revelation was followed by a three-year pause (a period known as fatra) during which Muhammad felt depressed and further gave himself to prayers and spiritual practices.[62] When the revelations resumed he was reassured and commanded to begin preaching: "Thy Guardian-Lord hath not forsaken thee, nor is He displeased."[65][66][67]
A depiction of Muhammad receiving his first revelation from the angel Gabriel. From the manuscript Jami' al-tawarikh by Rashid-al-Din Hamadani, 1307, Ilkhanate period.
Sahih Bukhari narrates Muhammad describing his revelations as "sometimes it is (revealed) like the ringing of a bell". Aisha reported, "I saw the Prophet being inspired Divinely on a very cold day and noticed the sweat dropping from his forehead (as the Inspiration was over)".[68] According to Welch these descriptions may be considered genuine, since they are unlikely to have been forged by later Muslims.[15] Muhammad was confident that he could distinguish his own thoughts from these messages.[69] According to the Quran, one of the main roles of Muhammad is to warn the unbelievers of theireschatological punishment (Quran 38:70, Quran 6:19). Occasionally the Quran did not explicitly refer to Judgment day but provided examples from the history of extinct communities and warns Muhammad's contemporaries of similar calamities (Quran 41:13–16).[21] Muhammad did not only warn those who rejected God's revelation, but also dispensed good news for those who abandoned evil, listening to the divine words and serving God.[70] Muhammad's mission also involves preaching monotheism: The Quran commands Muhammad to proclaim and praise the name of his Lord and instructs him not to worship idols or associate other deities with God.[21][71]
The key themes of the early Quranic verses included the responsibility of man towards his creator; the resurrection of the dead, God's final judgment followed by vivid descriptions of the tortures in Hell and pleasures in Paradise, and the signs of God in all aspects of life. Religious duties required of the believers at this time were few: belief in God, asking for forgiveness of sins, offering frequent prayers, assisting others particularly those in need, rejecting cheating and the love of wealth (considered to be significant in the commercial life of Mecca), being chaste and not to kill newborn girls.[15]

21

my sources tell me that it's time to pull out paper shredder

by poopie in

jw
friends

at bethel.

they have dug themselves deep in hole they are shreddin documents little by little so stuart anderson cannot get his hands on documents that would cause them to open those wallets the shunning policy is being questioned so much

Brokeback Watchtower

Here's some SAs:

http://www.menuism.com/restaurant-locations/stuart-andersons-black-angus-180886

40

Two Year Delay in Building New KHs - What Is the Real Impact?

by committeechairman in

where are all these kingdom halls that were going to start being built?

the rbc arrangement was officially announced as an arrangement that was ending in the united states branch territory in a letter on january 24, 2014 (although this letter is no longer listed on jw.org).

this means that 23 months have passed since the announcement of the ldc taking over and "acceleration" of kingdom hall builds.. what has happened in the meantime with kh construction?

Brokeback Watchtower

Knowing the Governing Body are such haters of getting a higher education they may have a very poor accountants running their accounting system and so failed to notify the Governing Body about gravity of the situation, partly because they are all ass kissers and yes men of the GB and they know how the GB react toward bringers of bad news and so fudged things a little finally after years of poor accounting the shit has finally hit the fan for the GB and all their ass kissers in the accounting department. Perhaps for this reason they would absolutely hate an audit by the IRS.

Kinda make you wonder what kind of business meeting the GB have to keep them informed about things in the financial department

40

Two Year Delay in Building New KHs - What Is the Real Impact?

by committeechairman in

where are all these kingdom halls that were going to start being built?

the rbc arrangement was officially announced as an arrangement that was ending in the united states branch territory in a letter on january 24, 2014 (although this letter is no longer listed on jw.org).

this means that 23 months have passed since the announcement of the ldc taking over and "acceleration" of kingdom hall builds.. what has happened in the meantime with kh construction?

Brokeback Watchtower

Maybe they made their decision to keep everything going for as long as they did was because they hoped that all the pledges would be honored and so they proceeded to rely on what was pledged at their massive pledge drive. Then as the months rolled on they maybe got 1/2 with a steadily desending trend and so all the cut backs happening now. But they just can't come out and say that and in order not to have donation dry up completely they are saying everything was good at the donation giving end and that they simply over spent the master's money.